抗体

抗CHOP抗体

A00311

100微升

200美元

多克隆

兔

nonconjugated

人类, 小鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗CHOP抗体

200美元

Synthesized peptide derived from human CHOP around the non-phosphorylation site of S30.

Liquid

兔

液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠

免疫原亲和纯化

多克隆

Rabbit Polyclonal Antibody for CHOP Antibody (DDIT3) detection. Tested with WB, IHC, IF in Human, Mouse.

100微升

人类;小鼠

IF;免疫组化;免疫印迹

DNA damage-inducible transcript 3 protein

DDIT3

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.

epigenetics and nuclear signaling transcription other factors stem cells embryonic stem cells intracellular developmental biology embryogenesis surface molecules metabolism types of disease diabetes obesity metabolic disorders

Store at -20 for one year, at 4 for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20℃ upon receiving. Avoid repeated freezing and thawing.

Cytoplasm. Nucleus. Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.

DNA damage-inducible transcript 3 protein;DDIT-3;C/EBP zeta;C/EBP-homologous protein;CHOP;C/EBP-homologous protein 10;CHOP-10;CCAAT/enhancer-binding protein homologous protein;Growth arrest and DNA damage-inducible protein GADD153;DDIT3;CHOP, CHOP10, GADD153;

P35638