产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗DNMT3B抗体
目录 :
A00319
规格 :
100微升
价格 :
269美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
产品信息
SKU号 :
A00319
名称 :
抗DNMT3B抗体
价格 :
269美元
免疫原 :
Synthesized peptide derived from N-terminal of human DNMT3B.
形式 :
Liquid
宿主 :
兔
contents :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
纯化 :
免疫原亲和纯化
克隆性 :
多克隆
描述 :
Rabbit Polyclonal Antibody for DNMT3B (DNMT3B) detection. Tested with WB, IHC, IF in Human.
规格 :
100微升
反应物种 :
人类
应用 :
IF;免疫组化;免疫印迹
基因全称 :
DNA (cytosine-5)-methyltransferase 3B
基因名称 :
DNMT3B
protein function :
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
研究种类 :
epigenetics and nuclear signaling dna methylation dnmts
epigenetics and nuclear signaling chip'ing antibodies
储存 :
Store at -20 for one year, at 4 for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20℃ upon receiving. Avoid repeated freezing and thawing.
subcellular localization :
Nucleus .
同义词 :
DNA (cytosine-5)-methyltransferase 3B;Dnmt3b;2.1.1.37;DNA methyltransferase HsaIIIB;DNA MTase HsaIIIB;M.HsaIIIB;DNMT3B;
组织特异性 :
Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.
UniProt数据库编号 :
Q9UBC3
更多信息或购买 :
公司信息
武汉博士德生物工程有限公司
Premium Provider of Antibodies and ELISA Kits