抗体

抗人类TLR1 DyLight系列染料®488共轭标签抗体

A00429-Dyl488

50 ug/vial

415美元

多克隆

domestic rabbit

DyLight488

抗人类TLR1 DyLight系列染料®488共轭标签抗体

415美元

50 ug/vial

多克隆

兔

DyLight系列染料®488

人类

流式细胞仪

流式细胞仪, 1-3μg/1x10^6细胞

Boster Bio Anti-Human TLR1 DyLight® 488 conjugated Antibody catalog # A00429-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

TLR1

Q15399

E. coli-derived human TLR1 recombinant protein (Position: F350-D404).

液体

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

No cross reactivity with other proteins.

At 2-8?C for one year from date of receipt. Protect from light. Do not freeze.

Toll样受体1

Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281; TLR1; KIAA0012

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

细胞膜

Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

Toll-like receptor 1 (TLR1), also called TIL or CD281 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. This gene is mapped to 4p14 by fluorescence in situ hybridization. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.

Adapters, Immunoglobulins, Immunology, Innate Immunity, Macrophage / Inflamm., Nfkb Pathway, Nuclear Signaling, Receptors, Signal Transduction, Signaling Pathway, Tlr Signaling, Transmembrane