抗体

Anti-Fibrinogen alpha chain/FGA Antibody Picoband™

A00816-1

100μg/vial

315美元

多克隆

domestic rabbit

未共轭

人类, 大鼠

Anti-Fibrinogen alpha chain/FGA Antibody Picoband™

315美元

100μg/vial

多克隆

兔

人类, 大鼠

免疫印迹

免疫印迹, 0.1 0.5µg/毫升, 人类, 大鼠

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Boster Bio Anti-Fibrinogen alpha chain/FGA Antibody Picoband™ catalog # A00816-1. Tested in WB applications. This antibody reacts with Human, Rat.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

FGA

P02671

different from the related mouse and rat sequences by two amino acids.
RTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLR
VE),
A synthetic peptide corresponding to a sequence at the C-terminus of human FGA (687-727aa

冻干

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

免疫原亲和纯化

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

纤维蛋白原甲链

纤维蛋白原甲链;血纤维蛋白肽a;纤维蛋白原甲链;FGA;

纤维蛋白原甲链

94973分子量

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

Secreted.

Detected in blood plasma (at protein level).

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing.

Atherosclerosis, Cardiovascular, Metabolism, Platelets