武汉博士德生物工程有限公司

抗体

抗C-kit抗体

A01335

100微升

200美元

多克隆

兔

nonconjugated

人类, 小鼠

免疫印迹, 免疫组化

A01335

抗C-kit抗体

200美元

Synthesized peptide derived from human c-Kit around the non-phosphorylation site of Y936.

Liquid

兔

液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠

免疫原亲和纯化

多克隆

Rabbit Polyclonal Antibody for c-Kit Antibody (KIT) detection. Tested with WB, IHC in Human, Mouse.

100微升

人类;小鼠

免疫组化;免疫印迹

Mast/stem cell growth factor receptor Kit

KIT

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

immunology cell type markers cytokines tags & cell markers tumor associated signal transduction protein phosphorylation tyrosine kinases receptor tyrosine kinases neuroscience neurotransmission receptors / channels tyrosine kinase receptors stem cells germline stem cells embryonic germ cells hematopoietic progenitors surface molecules cancer oncoproteins/suppressors oncoproteins growth factor receptors myeloid mast cell lineage hematopoietic stem cells hsc markers developmental biology reproduction germ cell markers organogenesis hematopoietic system development

Store at -20 for one year, at 4 for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20℃ upon receiving. Avoid repeated freezing and thawing.

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Mast/stem cell growth factor receptor Kit;SCFR;2.7.10.1;Piebald trait protein;PBT;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;p145 c-kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;CD117;KIT;SCFR;

Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells.

P10721