产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗cIAP-1/HIAP-2抗体
目录 :
A01700
规格 :
50微升
价格 :
299美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫沉淀
图像
图像 1 :
武汉博士德生物工程有限公司 A01700 图像 1
Immunohistochemical analysis of cIAP1 in formalin-fixed, paraffin-embedded human prostate using primary antibody dilution ratio of 1:2000. A, normal prostate. B, prostate intraepithelial neoplasia (PIN). PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-eosin counterstain. Increased cIAP1 expression is PIN and in prostate cancer compared to normal prostate.
图像 2 :
武汉博士德生物工程有限公司 A01700 图像 2
Western blot analysis of cIAP1 in human prostate using primary antibody dilution ratio of 1:1000. PBH (benign prostate hyperplasia), PIN (prostate intraepithelial neoplasia). Elevated levels of cIAP1 were seen in certain cases of BPH/PIN and prostate cancer compared to normal prostate.
产品信息
SKU号 :
A01700
状态 :
Enabled
名称 :
抗cIAP-1/HIAP-2抗体
目录名称 :
一抗, 多克隆抗体, 免疫组化免疫细胞化学IF抗体
基因名称 :
BIRC2
价格 :
299美元
price various sizes :
50 ul / $299 50 ul+Free HRP Secondary BA1054 / $299 50 ul+Free Biotin Secondary BA1003 / $299
克隆性 :
多克隆
浓度 :
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
共轭标签 :
No
contents :
50 ul sera
描述 :
Polyclonal antibody for CIAP1/BIRC2 detection. Host: Rabbit.Size: 100 ug. Tested applications: IP. Reactive species: Canine. CIAP1/BIRC2 information: Molecular Weight: 69900 MW; Subcellular Localization: Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells; Tissue Specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
short description :
Rabbit IgG Polyclonal antibody for BIRC2 detection. Tested with WB, IHC, IP in Dog, Gerbil, Human, Mouse, Rat.
规格 :
50微升
sample size available :
No sample size available
UniProt数据库编号 :
Q13490
宿主 :
免疫原 :
全长重组蛋白人的cAIP1
形式 :
Liquid
储存 :
Store the antibody at 4 C, stable for 6 months. For long-term storage, store at -20 C. Avoid repeated freeze and thaw cycles.
应用细节 :
WB, 1:1000-1:2000. IHC (paraffin), 1:1000-1:5000. IHC (frozen), Users should optimize. IP, 1:50-1:200.
应用 :
免疫沉淀, 免疫组化, 免疫印迹
反应物种 :
狗, 人类, 小鼠, 大鼠
图像标记 :
Immunohistochemical analysis of cIAP1 in formalin-fixed, paraffin-embedded human prostate using primary antibody dilution ratio of 1:2000. A, normal prostate. B, prostate intraepithelial neoplasia (PIN). PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-eosin counterstain. Increased cIAP1 expression is PIN and in prostate cancer compared to normal prostate. Western blot analysis of cIAP1 in human prostate using primary antibody dilution ratio of 1:1000. PBH (benign prostate hyperplasia), PIN (prostate intraepithelial neoplasia). Elevated levels of cIAP1 were seen in certain cases of BPH/PIN and prostate cancer compared to normal prostate.
competitor equivalent skus :
sc 5944 sc 5945 sc 5947 sc 367803 sc 5944 X sc 5945 X sc 367803 X sc 5947 X
研究种类 :
Apoptosis, Apoptotic Markers, Cancer, Cancer Metabolism, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways And Processes, Receptors, Response To Hypoxia
同义词 :
Baculoviral IAP repeat-containing protein 2;6.3.2.-;Cellular inhibitor of apoptosis 1;C-IAP1 ;IAP homolog B;Inhibitor of apoptosis protein 2;hIAP-2;hIAP2;RING finger protein 48;TNFR2-TRAF-signaling complex protein 2;BIRC2;API1, MIHB, RNF48;
基因全称 :
Baculoviral IAP repeat-containing protein 2
分子量 :
69900分子量
protein function :
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
subcellular localization :
Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
组织特异性 :
Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
蛋白名 :
Baculoviral IAP repeat-containing protein 2
更新 :
2/6/19 22:57
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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