抗体

抗PHLPP2抗体

A04110

100微克/200微升

290美元

多克隆

山羊

nonconjugated

抗PHLPP2抗体

290美元

Synthetic peptide with sequence C-PHEEDRTEPPEEFD, corresponding to the C Terminus of the protein sequence.

Liquid

山羊

Each vial contains the specific antibody at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

免疫原亲和纯化

多克隆

Goat Anti-PHLPP2 Antibody for PHLPPL detection tested with WB in Human.

100微克/200微升

人类

免疫印迹

PH domain leucine-rich repeat-containing protein phosphatase 2

PHLPP2

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser- 473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).

PH domain leucine-rich repeat-containing protein phosphatase 2

signal transduction protein phosphorylation ser / thr phosphatases signal transduction ser / thr kinases pkb / akt

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.

PH domain leucine-rich repeat-containing protein phosphatase 2;3.1.3.16;PH domain leucine-rich repeat-containing protein phosphatase-like;PHLPP-like;PHLPP2;KIAA0931, PHLPPL;

In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).

Q6ZVD8