抗体

抗LGP2抗体

A04121

50 ug/vial

275美元

多克隆

兔

nonconjugated

免疫印迹, 免疫沉淀

抗LGP2抗体

275美元

Synthetic peptide corresponding to 15 aa near the C-terminus of human LGP2.

Liquid

兔

Each vial contains 0.02% sodium azide.

表位亲和纯化

多克隆

Rabbit Anti-LGP2 Antibody for DHX58 detection tested with IP, WB in Human.

50 ug/vial

人类

免疫沉淀;免疫印迹

1毫克/毫升

Probable ATP-dependent RNA helicase DHX58

DHX58

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Probable ATP-dependent RNA helicase DHX58 (DHX58)

epigenetics and nuclear signaling dna / rna rna processing immunology immune system diseases antiviral signaling

At -20 for one year. After reconstitution, at 4 for one month. It can also be aliquotted and stored frozen at -20 for a longer time. Avoid repeated freezing and thawing.

细胞质

Probable ATP-dependent RNA helicase DHX58;3.6.4.13;Probable ATP-dependent helicase LGP2;Protein D11Lgp2 homolog;RIG-I-like receptor 3;RLR-3;RIG-I-like receptor LGP2;RLR;DHX58;D11LGP2E, LGP2;

Q96C10