产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗p53K372me1抗体
目录 :
CI1045
规格 :
50微克/25微升
价格 :
380美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 染色质免疫沉淀
产品信息
SKU号 :
CI1045
名称 :
抗p53K372me1抗体
价格 :
380美元
免疫原 :
This antibody is raised in rabbit against human p53 (tumor protein p53), methylated at K372, using a KLH-conjugated synthetic peptide.
形式 :
Liquid
宿主 :
contents :
蛋白质G纯化多克隆抗体在PBS含0.05% 叠氮化物和0.05% ProClin防腐剂300
纯化 :
蛋白质G纯化
克隆性 :
多克隆
描述 :
Rabbit IgG polyclonal antibody for human p53 (tumor protein p53), methylated at K372. Tested with WB,ChIP in Human.
规格 :
50微克/25微升
反应物种 :
人类
应用 :
ChIP;ChIP-qPCR;免疫印迹
背景 :
The transcription factor p53 is a tumour suppressor that regulates the cellular response to diverse cellular stresses. Upon activation, p53 induces several target genes which leads to cell cycle arrest and DNA repair, or alternatively, to apoptosis. In unstressed cells, p53 is kept inactive by the ubiquitin ligase MDM2 which inhibits the activity and promotes the degradation. p53 is a short-lived protein which is activated and stabilized via different post-translational modifications. One of these modifications, methylation of lysine 372 has been shown to positively affect the stability of p53. Mutations in p53 are involved in a vast majority of human cancers.
基因全称 :
Cellular tumor antigen p53
基因名称 :
TP53
protein function :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1- mediated transcriptional activation of PER2 (PubMed:24051492).
蛋白名 :
Cellular tumor antigen p53
研究种类 :
cell biology apoptosis intracellular p53 pathway
sequence similarities :
Belongs to the p53 family.
储存 :
At -20 for one year, at 4 for one month. Avoid repeated freezing and thawing.
subcellular localization :
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress.
同义词 :
Cellular tumor antigen p53;Antigen NY-CO-13;Phosphoprotein p53;Tumor suppressor p53;TP53;P53;
组织特异性 :
Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
UniProt数据库编号 :
P04637
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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