产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
Mouse FASL ELISA Kit PicoKine®
目录 :
EK0338
规格 :
96 wells/kit, with removable strips.
价格 :
399美元
图像
图像 1 :
武汉博士德生物工程有限公司 EK0338 图像 1
Mouse FASL PicoKine ELISA Kit standard curve
产品信息
SKU号 :
EK0338
产品名称 :
Mouse FASL ELISA Kit PicoKine®
规格 :
96 wells/kit, with removable strips.
价格 :
399美元
描述 :
Mouse FASL ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Faslg in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.
反应物种 :
小鼠
应用 :
酶联免疫吸附测定
基因名称 :
FASLG
UniProt数据库编号 :
P41047
免疫原 :
Expression system for standard: NS0; Immunogen sequence: P132-L279
交叉活性 :
There is no detectable cross-reactivity with other relevant proteins.
试验范围 :
31.2 pg/ml - 2,000 pg/ml
敏感性 :
<10 pg/ml
样品类型 :
cell culture supernatants, serum and plasma (heparin, EDTA, citrate)
Capture/Detection Antibodies :
单克隆抗体来自大鼠, 多克隆抗体来自山羊
储存 :
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
基因全称 :
Tumor necrosis factor ligand superfamily member 6
同义词 :
Tumor necrosis factor ligand superfamily member 6;CD95 ligand;CD95-L;Fas antigen ligand;Fas ligand;FasL;CD178;Tumor necrosis factor ligand superfamily member 6, membrane form;Tumor necrosis factor ligand superfamily member 6, soluble form;Receptor-binding FasL ectodomain;Soluble Fas ligand;sFasL;ADAM10-processed FasL form;APL;FasL intracellular domain;FasL ICD;SPPL2A-processed FasL form;SPA;Faslg;Apt1lg1, Cd95l, Fasl, gld, Tnfsf6;
蛋白名 :
Tumor necrosis factor ligand superfamily member 6
分子量 :
31442分子量
Protein Function :
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:7511063). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:19794494, PubMed:7532682). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (PubMed:19794494). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (PubMed:10779162). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity).
Subcellular Localization :
Isoform FasL: Cell membrane ; Single- pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane.
组织特异性 :
Expressed in T-cells (PubMed:19794494). Expressed in natural killer cells (PubMed:7532682).
Sequence Similarities :
含1死亡区域
背景 :
FAS Ligand (FASL) is a 40 kDa type II membrane protein belonging to the tumor necrosis factor family, which induces apoptosis by binding to its receptor, Fas. The human FasL gene consists of approximately 8.0 kb and is split into four exons. This gene consists of 281 amino acids with a calculated M (r) of 31,759 and was mapped on chromosome 1q23. It has an identity of 76.9% at the amino acid sequence level with mouse FasL. The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis. FAS and FASL triggered apoptosis pathway plays an important role in human carcinogenesis. This system may also play a role in modulating the genetic susceptibility of mouse strains to develop T-cell lymphoblastic lymphomas.
研究种类 :
Hematopoietic Progenitors, Immunology, Innate Immunity, Intracellular, Lymphoid, Receptors, Stem Cells, T Lymphocytic Lineage, Tnf Superfamily
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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