产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
Rat IGF-1 ELISA Kit PicoKine®
目录 :
EK0377
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
文章摘录数: 1
参考文献
Talebpour Amiri F, Fadaei Fathabadi F, Mahmoudi Rad M, Piryae A, Ghasemi A, Khalilian A, et al. The effects of insulin-like growth factor-1 gene therapy and cell transplantation on rat acute wound model. Iran Red Crescent Med J. 2014;16:e16323 pubmed 出版商
图像
图像 1 :
武汉博士德生物工程有限公司 EK0377 图像 1
Rat IGF-1 PicoKine ELISA Kit standard curve
产品信息
SKU号 :
EK0377
产品名称 :
Rat IGF-1 ELISA Kit PicoKine®
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
描述 :
Rat IGF-1 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Igf1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 5 pg/ml.
反应物种 :
大鼠
前体活性 :
仓鼠
应用 :
酶联免疫吸附测定
基因名称 :
胰岛素样生长因子1
UniProt数据库编号 :
P08025
免疫原 :
Expression system for standard: E.coli; Immunogen sequence: G49-A118
交叉活性 :
There is detectable cross-reactivity with IGF-2< 1%.
试验范围 :
62.5 pg/ml - 4,000 pg/ml
敏感性 :
<5 pg/ml
样品类型 :
cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)
Capture/Detection Antibodies :
monoclonal antibody from mouse, polyclonal antibody from goat specific for IGF-1
储存 :
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
基因全称 :
胰岛素样生长因子I
同义词 :
胰岛素样生长因子I;IGF-I;促生长因子;胰岛素样生长因子1;胰岛素样生长因子1;
蛋白名 :
胰岛素样生长因子I
分子量 :
17079分子量
Protein Function :
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity).
Subcellular Localization :
Secreted.
Sequence Similarities :
Belongs to the insulin family.
背景 :
Insulin-like growth factor 1 (IGF-1) that was once called somatomedin C, is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. Human IGF1 is a single chain 70-amino acid polypeptide cross-linked by 3 disulfide bridges, with a calculated molecular mass of 7.6 kD. The IGF1 gene, mapped on 12q22-q24.1, contains 5 exons. Exons 1-4 encode the 195-amino acid precursor (IGF1B), and exons 1, 2, 3, and 5 encode the 153-residue peptide (IGF1A). The structure of IGF1 resembles that of IGF2. And the IGF1 and IGF2 genes have complex structures with multiple promoters. The expression of both genes is regulated at the levels of transcription, RNA processing, and translation. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Moreover, approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). Furthermore, IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.
研究种类 :
Cancer, Developmental Biology, Growth Factors, Growth Factors/Hormones, Signal Transduction
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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