产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
Mouse MMP-2 PicoKine ELISA Kit
目录 :
EK0460
规格 :
96 wells/kit
价格 :
400美元
产品信息
SKU号 :
EK0460
名称 :
Mouse MMP-2 PicoKine ELISA Kit
价格 :
400美元
免疫原 :
Expression system for standard: NSO; Immunogen sequence: A30-C662
描述 :
Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse MMP-2
规格 :
96 wells/kit
反应物种 :
小鼠
应用 :
酶联免疫吸附测定
背景 :
Type IV collagenase, 72-kD, is officially designated matrix metalloproteinase-2(MMP2). It is also known as gelatinase, 72-kD. MMP-2 plays an essential role in angiogenesis and arteriogenesis, two processes critical to restoration of tissue perfusion after ischemia. MMP-2 expression is increased in tissue ischemia, but the responsible mechanisms remain unknown. Matrix metalloproteinases(MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide(cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability. The gene is localized to 16q21 using somatic cell hybrids and in situ hybridization. The standard product used in this kit is recombinant mouse MMP-2, consisting of 662 amino acids with the molecular mass of 72KDa. The detected MMP-2 includes zymogen and active enzyme.
交叉活性 :
There is no detectable cross-reactivity with other relevant proteins.
基因全称 :
72kDa的IV型胶原酶
基因名称 :
MMP2;Mmp2
protein function :
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity).
蛋白名 :
72kDa的IV型胶原酶
研究种类 :
cardiovascular angiogenesis adhesion / ecm matrix metalloproteinases mmp cancer invasion/microenvironment extracellular matrix mmps cell biology proteolysis / ubiquitin proteolytic enzymes metalloprotease tumor biomarkers cancer metabolism response to hypoxia metabolism pathways and processes metabolism processes types of disease
sequence similarities :
Belongs to the peptidase M10A family.
储存 :
Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
subcellular localization :
Isoform 1: Secreted, extracellular space, extracellular matrix . Membrane . Nucleus . Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).
同义词 :
72kDa的IV型胶原酶;3.4。 24.24;72kDa的明胶酶;明胶酶a;基质金属蛋白酶2;基质金属蛋白酶-2;PEX;Mmp2;
UniProt数据库编号 :
P33434
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
www.boster.com.cn
925.485.4527
公司总部: 美国
Premium Provider of Antibodies and ELISA Kits