ELISA/assay

Human TGF Beta 1 PicoKine ELISA Kit

EK0513

96 wells/kit

300美元

Human TGF Beta 1 PicoKine ELISA Kit

300美元

Expression system for standard: CHO; Immunogen sequence: A279-S390

Sandwich High Sensitivity ELISA kit for Quantitative Detection of activated Human TGF beta 1

96 wells/kit

人类

酶联免疫吸附测定

Transforming growth factor-beta1(TGF-beta1) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects.TGFbeta1 is known for its potent and diverse biological effects, including immune regulation, and cell growth and differentiation.TGFbeta1 is also an important mediator of bone remodeling.TGFbeta1, a potent keratinocyte growth inhibitor, has been shown to be overexpressed in keratinocytes in certain inflammatory skin diseases and has been thought to counteract the effects of other growth factors at the site of inflammation.TGF-beta1, a multifunctional cytokine with fibrogenic properties, has been implicated in the pathogenesis of the vascular and target organ complications of hypertension. TGF-beta1 may also regulate blood pressure via stimulation of endothelin-1 and/or renin secretion. TGFbeta1 is secreted as a latent form, which consists of its mature form and a latency-associated peptide(beta1-LAP) in either the presence or the absence of additional latent TGF-beta1-binding protein. The standard product used in this kit is recombinant TGFbeta1 with the molecular mass of 25KDa.

There is cross-reactivity with TGF beta 2, TGF beta 3, TGF beta 5<1%.

转化生长因子β1

转化生长因子1

Bovine; Canine; Monkey; Rabbit

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.

转化生长因子β1

cardiovascular angiogenesis growth factors tgf signal transduction growth factors/hormones stem cells signaling pathways tgf beta secreted cancer invasion/microenvironment angiogenic growth factors developmental biology organogenesis angiogenesis and vasculogenesis cancer metabolism response to hypoxia metabolism pathways and processes cofactors, vitamins / minerals co-factors metabolism processes types of disease

Belongs to the TGF-beta family.

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Secreted, extracellular space, extracellular matrix .

Transforming growth factor beta-1;TGF-beta-1;Latency-associated peptide;LAP;TGFB1;TGFB;

Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.

P01137