ELISA/assay

Pig porcine TIMP-3 ELISA Kit PicoKine®

EK0523-PO

96 wells/kit, with removable strips.

400美元

Pig porcine TIMP-3 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

400美元

Pig porcine TIMP-3 ELISA Kit PicoKine® (96 Tests). Quantitate Pig TIMP3 in cell culture supernatants, serum, plasma (heparin, EDTA) and saliva. Sensitivity: 2pg/ml.

猪

酶联免疫吸附测定

TIMP3

P35625

Expression system for standard: NS0; Immunogen sequence: C24-P211

There is no detectable cross-reactivity with other relevant proteins.

156 pg/ml - 10,000 pg/ml

<2 pg/ml

cell culture supernatants, serum, plasma (heparin, EDTA) and saliva

单克隆抗体来自小鼠, 多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Metalloproteinase inhibitor 3

Metalloproteinase inhibitor 3;Protein MIG-5;Tissue inhibitor of metalloproteinases 3;TIMP-3;TIMP3;

Metalloproteinase inhibitor 3

24145分子量

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

Secreted, extracellular space, extracellular matrix.

Belongs to the protease inhibitor I35 (TIMP) family.

The tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy (SFD).

Angiogenesis, Apoptosis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Neuroscience, Protease Inhibitors, Proteolysis / Ubiquitin, Sensory System, Signal Transduction, Visual System