ELISA/assay

Human Endoglin/CD105/ENG ELISA Kit PicoKine®

EK0644

1

Human Endoglin/CD105/ENG ELISA Kit PicoKine®

人类cd105

Picokine ELISA Kits

ENG

400

156 pg/ml - 10,000 pg/ml

Human CD105 ELISA Kit PicoKine (96 Tests). Quantitate Human ENG in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.

Human CD105 ELISA Kit PicoKine (96 Tests). Quantitate Human ENG in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.

96 wells/kit, with removable strips.

P17813

Expression system for standard: CHO; Immunogen sequence: E26-G586

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

There is no detectable cross-reactivity with other relevant proteins.

<15 pg/ml

10 ng/tube

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).

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Human CD105 PicoKine ELISA Kit standard curve

Concentration (pg/ml) 0 156 312 625 1250 2500 5000 10000 O.D. 0.011 0.122 0.258 0.471 0.766 1.312 1.658 2.022

5/17/14 9:17

3/2/22 2:54

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Human Endoglin/CD105/ENG ELISA Kit Price PicoKine® BosterBio

Human CD105 ELISA Kit, Endoglin ELISA Kit, Bosterbio High Sensitivity

97.9

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10,000 pg/ml, 5,000 pg/ml, 2,500 pg/ml, 1,250 pg/ml, 625 pg/ml, 312 pg/ml, 156 pg/ml

CD105, also called Endoglin, is a homodimeric membrane glycoprotein primarily associated with human vascular endothelium. It is also found on bone marrow proerythroblasts, activated monocytes, and lymphoblasts in childhood leukemia. Endoglin is a component of the transforming growth factor-beta (TGFB) receptor complex and binds TGFB1 with high affinity.1 CD105 gene is mapped to 9q34.1. The coding region of the gene contains 14 exons.2 The protein consists of a homodimer of 180 kDA with disulfide links. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. Furthermore, it also has a role in the balance of ALK1 and ALK5 signaling to regulate endothelial cell proliferation.3 Moreover, the elevated expression of endoglin in the surgically excised CNVMs suggested a persisting postmitotic activation in an advanced stage of neovascular tissue.4 The standard product used in this kit is extracellular part of recombinant human CD105, from E26 to G586. As a result of glycosylation, the molecular mass is 75-85KDa.

Epigenetics And Nuclear Signaling,Neurogenesis,Neurology Process,Neuroscience,Transcription

Endoglin;CD105;ENG;END;

Endoglin

70578分子量

Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.

Membrane; Single-pass type I membrane protein.

Endoglin is restricted to endothelial cells in all tissues except bone marrow.

Endoglin

Intra-Assay Precision Inter-Assay Precision Sample 1 2 3 1 2 3 n 16 16 16 24 24 24 Mean (pg/ml) 312 1384 4821 316 1275 4955 Standard deviation 16.22 74.73 318.18 17.38 72.67 386.49 CV (%) 5.2% 5.4% 6.6% 5.5% 5.7% 7.8%

Lots Lot 1 (pg/ml) Lot 2 (pg/ml) Lot 3 (pg/ml) Lot 4 (pg/ml) Mean (pg/ml) Standard Deviation CV (%) Sample 1 312 285 280 306 295 13.53 4.5% Sample 2 1384 1301 1412 1238 1333 68.71 5.1% Sample 3 4821 5271 4779 5474 5086 295.48 5.8% *number of samples for each test n=16.

15-25min

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22453150

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