产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
Human Endostatin PicoKine ELISA Kit
目录 :
EK0886
规格 :
96 wells/kit
价格 :
333美元
产品信息
SKU号 :
EK0886
名称 :
Human Endostatin PicoKine ELISA Kit
价格 :
333美元
免疫原 :
Expression system for standard: E.coli; Immunogen sequence: H1154-S1335
描述 :
Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Endostatin
规格 :
96 wells/kit
反应物种 :
人类
应用 :
酶联免疫吸附测定
背景 :
Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. And it is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. Using a genomic clone as a probe for fluorescence in situ hybridization, Endostatin was mapped the COL18A1 gene to 21q22.3. By immunoprecipitation analysis using membrane fractions of human mammary epithelial cells, It showed that endostatin specifically bound to cell surface nucleolin with high affinity. Blockage of nucleolin with neutralizing antibody or knockdown of nucleolin by RNA interference countered the antiendothelial activity of endostatin and abrogated its antiangiogenic and antitumor activity in vivo.
交叉活性 :
There is no detectable cross-reactivity with other relevant proteins.
基因全称 :
胶原甲1(XVIII)链
基因名称 :
COL18A1
protein function :
COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
蛋白名 :
胶原甲1(XVIII)链
研究种类 :
Nothing Found
sequence similarities :
Belongs to the multiplexin collagen family.
储存 :
Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
subcellular localization :
Secreted, extracellular space, extracellular matrix .
同义词 :
胶原甲1(XVIII)链;内皮抑素;COL18A1;
组织特异性 :
Present in multiple organs with highest levels in liver, lung and kidney.
UniProt数据库编号 :
P39060
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
www.boster.com.cn
925.485.4527
公司总部: 美国
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