ELISA/assay

Human Angiostatin Kringle 1-3/PLG ELISA Kit PicoKine®

EK0905

96 wells/kit, with removable strips.

430美元

Human Angiostatin Kringle 1-3/PLG ELISA Kit PicoKine®

96 wells/kit, with removable strips.

430美元

Human Angiostatin Kringle 1-3/PLG ELISA Kit PicoKine® (96 Tests). Quantitate Human PLG in cell culture supernatants, serum and plasma (heparin, EDTA) . Sensitivity: 10pg/ml.

人类

酶联免疫吸附测定

PLG

P00747

Expression system for standard: NS0; Immunogen sequence: V98-S355 (K1-3)

There is no detectable cross-reactivity with other relevant proteins.

156 pg/ml - 10,000 pg/ml

<10 pg/ml

cell culture supernatants, serum and plasma (heparin, EDTA)

单克隆抗体来自小鼠, 多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

纤溶酶原

Plasminogen;3.4.21.7;Plasmin heavy chain A;Activation peptide;Angiostatin;Plasmin heavy chain A, short form;Plasmin light chain B;PLG;

纤溶酶原

90569分子量

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.

Secreted . Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.

Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Belongs to the peptidase S1 family. Plasminogen subfamily.

Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. It displays increased inhibitory activity (ED₅₀ =70 nM) relative to kringles 1-4 (ED₅₀ = 135 nM).

Cardiovascular, Cell Biology, Platelets, Protease Inhibitors, Proteolysis / Ubiquitin, Proteolytic Enzymes