ELISA/assay

Human TLR3/Toll-like receptor 3 ELISA Kit PicoKine®

EK0907

96 wells/kit, with removable strips.

400美元

Human TLR3/Toll-like receptor 3 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

400美元

Human TLR3/Toll-like receptor 3 ELISA Kit PicoKine® (96 Tests). Quantitate Human TLR3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

人类

酶联免疫吸附测定

Toll样受体3

O15455

Expression system for standard: NS0; Immunogen sequence: K27-S711

There is no detectable cross-reactivity with other relevant proteins.

156 pg/ml - 10,000 pg/ml

<10 pg/ml

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

单克隆抗体来自小鼠, 多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Toll样受体3

Toll样受体3;CD283;Toll样受体3;

Toll样受体3

103829分子量

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.

Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.

Belongs to the Toll-like receptor family.

Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. The TLR3 gene was mapped to chromosome 4q35 by fluorescence in situ hybridization. TLR3 specifically recognizes double-stranded RNA (dsRNA) and induces multiple intracellular events responsible for innate antiviral immunity against a number of viral infections.

Chemokines, Host Virus Interaction, Immune System Diseases, Immunoglobulins, Immunology, Innate Immunity, Interspecies Interaction, Macrophage / Inflamm., Microbiology, Nfkb Pathway, Nuclear Signaling, Receptors, Signal Transduction, Signaling Pathway, Tlr Signaling