ELISA/assay

Mouse Chitinase 3-like 1/YKL-40 ELISA Kit PicoKine®

EK0975

96 wells/kit, with removable strips.

369美元

Mouse Chitinase 3-like 1/YKL-40 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369美元

Mouse Chitinase 3-like 1/YKL-40 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Chi3l1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

小鼠

酶联免疫吸附测定

CHI3L1

Q61362

Expression system for standard: NS0; Immunogen sequence: Y22-A381

There is no detectable cross-reactivity with other relevant proteins.

62.5 pg/ml - 4,000 pg/ml

<10 pg/ml

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

单克隆抗体来自大鼠, 多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

几丁质酶3蛋白1

几丁质酶3蛋白1;BRP39蛋白;胸、乳房回归蛋白39;软骨糖蛋白39;CGP-39;GP-39;Chi3l1;Brp39, Chil1;

几丁质酶3蛋白1

43893分子量

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Secreted, extracellular space. Cytoplasm. Endoplasmic reticulum. Detected in bronchoalveolar lavage (BAL) fluids. Localizes mainly to endoplasmic reticulum when overexpressed in cells, with some protein also detected throughout the cytoplasm.

Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon.

Belongs to the glycosyl hydrolase 18 family.

Chitinase-3-like protein 1, also called CHI3L1 or YKL-40 is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. This gene is mapped to 1q32.1. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

Cytoskeleton / Ecm, Ecm Proteins, Extracellular Matrix, Signal Transduction