ELISA/assay

Human Granzyme B ELISA Kit PicoKine®

EK1114

96 wells/kit, with removable strips.

369美元

Human Granzyme B ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369美元

Human Granzyme B ELISA Kit PicoKine® (96 Tests). Quantitate Human GZMB in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

人类

酶联免疫吸附测定

GZMB

P10144

Expression system for standard: NS0; Immunogen sequence: I21-Y247

There is no detectable cross-reactivity with other relevant proteins.

15.6 pg/ml - 1,000 pg/ml

<10 pg/ml

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

单克隆抗体来自小鼠, 多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

颗粒酶B

Granzyme B;3.4.21.79;C11;CTLA-1;Cathepsin G-like 1;CTSGL1;Cytotoxic T-lymphocyte proteinase 2;Lymphocyte protease;Fragmentin-2;Granzyme-2;Human lymphocyte protein;HLP;SECT;T-cell serine protease 1-3E;GZMB;CGL1, CSPB, CTLA1, GRB;

颗粒酶B

27716分子量

This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Cytoplasmic granule . Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Belongs to the peptidase S1 family. Granzyme subfamily.

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Adaptive Immunity, Apoptosis, Cell Biology, Immunology, Innate Immunity, Nk Cells, T Cells