产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
Human LAP(TGF-Beta1) ELISA Kit PicoKine®
目录 :
EK1218
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
文章摘录数: 1
参考文献
Uziel Y, Feldman B, Krafchik B, Laxer R, Yeung R. Increased serum levels of TGFbeta1 in children with localized scleroderma. Pediatr Rheumatol Online J. 2007;5:22 pubmed
图像
图像 1 :
武汉博士德生物工程有限公司 EK1218 图像 1
Human LAP(TGF-beta1) PicoKine ELISA Kit standard curve
产品信息
SKU号 :
EK1218
产品名称 :
Human LAP(TGF-Beta1) ELISA Kit PicoKine®
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
描述 :
Human LAP (TGF-Beta1) ELISA Kit PicoKine® (96 Tests). Quantitate Human TGFB1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.
反应物种 :
人类
应用 :
酶联免疫吸附测定
基因名称 :
转化生长因子1
UniProt数据库编号 :
P01137
免疫原 :
Expression system for standard: NS0; Immunogen sequence: L30-R278
交叉活性 :
There is no detectable cross-reactivity with other relevant proteins.
试验范围 :
62.5 pg/ml - 4,000 pg/ml
敏感性 :
<10 pg/ml
样品类型 :
cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)
Capture/Detection Antibodies :
单克隆抗体来自小鼠, 多克隆抗体来自山羊
储存 :
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
基因全称 :
转化生长因子β1
同义词 :
Transforming growth factor beta-1;TGF-beta-1;Latency-associated peptide;LAP;TGFB1;TGFB;
蛋白名 :
转化生长因子β1
分子量 :
44341分子量
Protein Function :
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
Subcellular Localization :
Secreted, extracellular space, extracellular matrix .
组织特异性 :
Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.
Sequence Similarities :
Belongs to the TGF-beta family.
背景 :
TGFbeta1 is secreted as a latent form, which consists of its mature form and a latency-associated peptide (beta1-LAP) in either the presence or the absence of additional latent TGF-beta1-binding protein. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells.
研究种类 :
Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Metabolism, Metabolism Processes, Organogenesis, Pathways And Processes, Response To Hypoxia, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Tgf Beta
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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