ELISA/assay

Mouse MADCAM-1 ELISA Kit PicoKine®

EK1332

96 wells/kit, with removable strips.

369美元

Mouse MADCAM-1 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369美元

Mouse MADCAM-1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Madcam1 in cell culture supernatants and serum. Sensitivity: 10pg/ml.

小鼠

酶联免疫吸附测定

MADCAM1

Q61826

Expression system for standard: NS0; Immunogen sequence: Q22-T365

There is no detectable cross-reactivity with other relevant proteins.

125 pg/ml - 8,000 pg/ml

<10 pg/ml

cell culture supernatants and serum

单克隆抗体来自大鼠, 多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Mucosal addressin cell adhesion molecule 1

Mucosal addressin cell adhesion molecule 1;MAdCAM-1;mMAdCAM-1;Madcam1;

Mucosal addressin cell adhesion molecule 1

43652分子量

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

Membrane; Single-pass type I membrane protein.

Highly expressed on high endothelial venules (HEV) of organized intestinal lymphoid tissues like the Peyer patches and mesenteric lymph nodes, and in the lamina propria of the intestine. Some expression found in the spleen, and low levels of expression in the peripheral lymph nodes and the lactating mammary gland. No expression was detected in the liver, kidneys, lungs or in normal brain. Expressed as well in brain endothelioma cells, and mucosal tissues which are in a chronic state of inflammation, such as inflammed pancreas.

MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1), also known as MACAM1, is a protein that is encoded by the MADCAM1 gene. By PCR-based analysis of somatic cell hybrids, Leung et al (1997) mapped the MACAM1 gene to chromosome 19. The protein encoded by this gene is an endothelil cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4/beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.

Angiogenesis, Cardiovascular, Cell Adhesion, Cell Adhesion Proteins, Cytoskeleton / Ecm, Immunology, Innate Immunity, Integrins, Macrophage / Inflamm., Neuroscience, Receptors, Signal Transduction