ELISA/assay

Mouse TIMP-4 ELISA Kit PicoKine®

EK1335

96 wells/kit, with removable strips.

369美元

Mouse TIMP-4 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369美元

Mouse TIMP-4 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Timp4 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

小鼠

酶联免疫吸附测定

TIMP4

Q9JHB3

Expression system for standard: NS0; Immunogen sequence: C30-P224

There is no detectable cross-reactivity with other relevant proteins.

78 pg/ml - 5,000 pg/ml

<10 pg/ml

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

单克隆抗体来自大鼠, 多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Metalloproteinase inhibitor 4

Metalloproteinase inhibitor 4;Tissue inhibitor of metalloproteinases 4;TIMP-4;Timp4;

Metalloproteinase inhibitor 4

25774分子量

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.

Secreted.

Expressed in brain, heart, ovary and skeletal muscle.

Belongs to the protease inhibitor I35 (TIMP) family.

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene. This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene is mapped to chromosome 3p25. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA. The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. Expressed TIMP4 inhibits MMPs in vitro. What’s more, TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Protease Inhibitors, Proteolysis / Ubiquitin