产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
Rat E-Cadherin/CDH1/Cadherin-1 ELISA Kit PicoKine®
目录 :
EK1434
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
产品信息
SKU号 :
EK1434
产品名称 :
Rat E-Cadherin/CDH1/Cadherin-1 ELISA Kit PicoKine®
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
描述 :
Rat E-Cadherin 1 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Cdh1 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 15pg/ml.
反应物种 :
大鼠
应用 :
酶联免疫吸附测定
基因名称 :
Cdh1
UniProt数据库编号 :
Q9R0T4
免疫原 :
Expression system for standard: NS0; Immunogen sequence: Q24-S704
交叉活性 :
There is no detectable cross-reactivity with other relevant proteins.
试验范围 :
156 pg/ml - 10,000 pg/ml
敏感性 :
<15 pg/ml
样品类型 :
cell culture supernatants, serum and plasma (heparin)
储存 :
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
基因全称 :
钙粘蛋白1
同义词 :
Cadherin-1;Epithelial cadherin;E-cadherin;Uvomorulin;CD324;E-Cad/CTF1;E-Cad/CTF2;E-Cad/CTF3;Cdh1;
蛋白名 :
钙粘蛋白1
分子量 :
98715分子量
Protein Function :
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity).
Subcellular Localization :
Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome . Golgi apparatus, trans-Golgi network . Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity).
背景 :
Cadherin-1, also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin, is a protein that in humans is encoded by the CDH1 gene. E-cadherin is a Ca (2+)-dependent epithelial cell-cell adhesion molecule. Downregulation of E-cadherin expression often correlates with strong invasive potential and poor prognosis of human carcinomas. The gene spans a region of approximately 100 kb, and its location on chromosome 16q22.1. It contains 16 exons and a 65-kb-long intron 2. E-cadherin gene mutations may contribute to the development of diffusely growing gastric carcinomas. It plays a central part in the process of epithelial morphogenesis and acts as a strong invasion suppressor in experimental tumor cell systems. The standard product used in this kit is recombinant gene expression with the molecular mass of 120KDa.
研究种类 :
Cadherins, Calcium Binding Proteins, Calcium Signaling, Cancer, Cell Adhesion, Cytoskeleton / Ecm, Invasion/Microenvironment, Signal Transduction, Signaling Pathway
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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