产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
Human ADA/Adenosine Deaminase ELISA Kit PicoKine®
目录 :
EK1446
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
图像
图像 1 :
武汉博士德生物工程有限公司 EK1446 图像 1
Human ADA PicoKine ELISA Kit standard curve
产品信息
SKU号 :
EK1446
产品名称 :
Human ADA/Adenosine Deaminase ELISA Kit PicoKine®
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
描述 :
Human ADA/Adenosine Deaminase ELISA Kit PicoKine® (96 Tests). Quantitate Human ADA in cell culture supernatants, serum and pleural fluid. Sensitivity: 10pg/ml.
反应物种 :
人类
应用 :
酶联免疫吸附测定
基因名称 :
ADA
UniProt数据库编号 :
P00813
免疫原 :
Expression system for standard: NS0; Immunogen sequence: A2-L363
交叉活性 :
There is no detectable cross-reactivity with other relevant proteins.
试验范围 :
31.2 pg/ml - 2,000 pg/ml
敏感性 :
<10 pg/ml
样品类型 :
cell culture supernatants, serum and pleural fluid.
Capture/Detection Antibodies :
a单克隆抗体来自小鼠, a生物素多克隆抗体来自山羊
储存 :
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
基因全称 :
腺苷脱氨酶
同义词 :
腺苷脱氨酶;3.5。 4.4;腺苷氨基水解酶;ADA;ADA1;
蛋白名 :
腺苷脱氨酶
分子量 :
40764分子量
Protein Function :
Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion.
Subcellular Localization :
Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen . Cytoplasm . Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.
组织特异性 :
Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.
背景 :
Adenosine Deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. ADA in humans is involved in the development and maintenance of the immune system. However, ADA association has also been observed with epithelial cell differentiation, neurotransmission, and gestation maintenance. It has also been proposed that ADA, in addition to adenosine breakdown, stimulates release of excitatory amino acids and is necessary to the coupling of A1 adenosine receptors and heterotrimeric G proteins. Adenosine deaminase deficiency leads to pulmonary fibrosis, suggesting that chronic exposure to high levels of adenosine can exacerbate inflammation responses rather than suppressing them. It has also been recognized that adenosine deaminase protein and activity is upregulated in mouse hearts that overexpress HIF-1 alpha, which in part explains the attenuated levels of adenosine in HIF-1 alpha expressing hearts during ischemic stress.
研究种类 :
Cancer, Cancer Metabolism, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Metabolism, Metabolism Processes, Pathways And Processes, Response To Hypoxia
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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