产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
Human Siglec5/Cd170 ELISA Kit PicoKine®
目录 :
EK1583
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
产品信息
SKU号 :
EK1583
产品名称 :
Human Siglec5/Cd170 ELISA Kit PicoKine®
规格 :
96 wells/kit, with removable strips.
价格 :
369美元
描述 :
Human Siglec5/Cd170 ELISA Kit PicoKine® (96 Tests). Quantitate Human SIGLEC5 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.
反应物种 :
人类
应用 :
酶联免疫吸附测定
基因名称 :
SIGLEC5
UniProt数据库编号 :
O15389
免疫原 :
Expression system for standard: NS0; Immunogen sequence: E17-L441
交叉活性 :
There is no detectable cross-reactivity with other relevant proteins.
试验范围 :
46.9 pg/ml - 3,000 pg/ml
敏感性 :
<15 pg/ml
样品类型 :
cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)
Capture/Detection Antibodies :
单克隆抗体来自小鼠, 多克隆抗体来自山羊
储存 :
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
基因全称 :
唾液酸结合免疫球蛋白样凝集素5
同义词 :
Sialic acid-binding Ig-like lectin 5;Siglec-5;CD33 antigen-like 2;Obesity-binding protein 2;OB-BP2;OB-binding protein 2;CD170;SIGLEC5;CD33L2, OBBP2;
蛋白名 :
唾液酸结合免疫球蛋白样凝集素5
分子量 :
60715分子量
Protein Function :
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Subcellular Localization :
Membrane; Single-pass type I membrane protein.
组织特异性 :
Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
背景 :
Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
研究种类 :
细胞类型标记, 免疫学
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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