ELISA/assay

Human Serpin A1/alpha 1-Antitrypsin ELISA Kit PicoKine®

EK1634

96 wells/kit, with removable strips.

399美元

Human Serpin A1/alpha 1-Antitrypsin ELISA Kit PicoKine®

96 wells/kit, with removable strips.

399美元

Human Serpin A1/alpha 1-Antitrypsin ELISA Kit PicoKine® (96 Tests). Quantitate Human SERPINA1 in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml .

人类

酶联免疫吸附测定

SERPINA1

P01009

Expression system for standard: NS0; Immunogen sequence: E25-K418

There is no detectable cross-reactivity with other relevant proteins.

1.56 ng/ml - 100 ng/ml

<10 pg/ml

cell culture supernatants, serum, plasma (heparin, EDTA) and urine

a单克隆抗体来自小鼠, a生物素多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

serpin family A member 1

Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; Short peptide from AAT; SPAAT; SERPINA1; AAT; PI; PRO0684; PRO2209

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

Secreted. Endoplasmic reticulum. The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.

Ubiquitous. Expressed in leukocytes and plasma.

Alpha-1-antitrypsin or α1-antitrypsin  (A1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1 gene. The gene is located on the long arm of the fourteenth chromosome  (14q32.1).The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Mutations in these areas can lead to non-functional proteins that can polymerise and accumulate in the liver (infantile hepatic cirrhosis).

Intracellular, Kinases, Metabolism, Metabolism Processes, Pathways And Processes, Protease Inhibitors, Proteolysis / Ubiquitin, Response To Hypoxia, Serum Proteins