ELISA/assay

Human Hyaluronidase1/HYAL1 ELISA Kit PicoKine®

EK1639

96 wells/kit, with removable strips.

369美元

Human Hyaluronidase1/HYAL1 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369美元

Human Hyaluronidase1/HYAL1 ELISA Kit PicoKine® (96 Tests). Quantitate Human HYAL1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

人类

酶联免疫吸附测定

HYAL1

Q12794

Expression system for standard: NS0; Immunogen sequence: F22-W435

There is no detectable cross-reactivity with other relevant proteins.

62.5 pg/ml - 4,000 pg/ml

<10 pg/ml

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

单克隆抗体来自小鼠, 生物素多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

hyaluronoglucosaminidase 1

Hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1; HYAL1; LUCA1

透明质酸酶1

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Secreted

Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.

Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

Cancer, Cytoskeleton / Ecm, Ecm Enzymes, Ecm Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction