ELISA/assay

Rat CXCL4/PF4 ELISA Kit PicoKine®

EK1651

96 wells/kit, with removable strips.

369美元

Rat CXCL4/PF4 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369美元

Rat CXCL4/PF4 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Pf4 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.

大鼠

酶联免疫吸附测定

Pf4

P06765

Expression system for standard: E.coli; Immunogen sequence: V30-S105

There is no detectable cross-reactivity with other relevant proteins.

156 pg/ml - 10,000 pg/ml

<15 pg/ml

cell culture supernatants, serum and plasma (heparin, EDTA)

单克隆抗体来自小鼠, 生物素多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

血小板因子

Platelet factor 4; PF-4; C-X-C motif chemokine 4; Pf4; Cxcl4; Scyb4

血小板因子

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.

Secreted.

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4). The PF4 gene was localized on 4q12-q13. Chemokines play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair.

Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Macrophage / Inflamm., Platelets, Vascular Inflammation