ELISA/assay

p63 (Phospho-Ser455) Colorimetric Cell-Based ELISA Kit

EKC2169

1 kit, containing 2 plates and all necessary reagents

480美元

p63 (Phospho-Ser455) Colorimetric Cell-Based ELISA Kit

1 kit, containing 2 plates and all necessary reagents

480美元

The p63 (Phospho-Ser455) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor p63 (Phospho-Ser455) protein expression profile in cells. The kit can be used for measuring the relative amounts of p63 (Phospho-Ser455) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on p63 (Phospho-Ser455).

人类

酶联免疫吸附测定

TP63

Q9H3D4

> 5000 Cells

>5000 cells

4°C/6 Months

肿瘤蛋白63

Tumor protein 63;p63;Chronic ulcerative stomatitis protein;CUSP;Keratinocyte transcription factor KET;Transformation-related protein 63;TP63;Tumor protein p73-like;p73L;p40;p51;TP63;KET, P63, P73H, P73L, TP73L;

76785分子量

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Nucleus .

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.