产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
ELISA/assay
产品名称 :
EGFR (Phospho-Tyr1069) Colorimetric Cell-Based ELISA Kit
目录 :
EKC2251
规格 :
1 kit, containing 2 plates and all necessary reagents
价格 :
480美元
产品信息
SKU号 :
EKC2251
产品名称 :
EGFR (Phospho-Tyr1069) Colorimetric Cell-Based ELISA Kit
规格 :
1 kit, containing 2 plates and all necessary reagents
价格 :
480美元
描述 :
The EGFR (Phospho-Tyr1069) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor EGFR (Phospho-Tyr1069) protein expression profile in cells. The kit can be used for measuring the relative amounts of EGFR (Phospho-Tyr1069) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on EGFR (Phospho-Tyr1069).
反应物种 :
人类, 小鼠, 大鼠
应用 :
酶联免疫吸附测定
基因名称 :
表皮生长因子受体
UniProt数据库编号 :
P00533
试验范围 :
> 5000 Cells
敏感性 :
>5000 cells
储存 :
4°C/6 Months
基因全称 :
表皮生长因子受体
同义词 :
Epidermal growth factor receptor;2.7.10.1;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;EGFR;ERBB, ERBB1, HER1;
分子量 :
134277分子量
Protein Function :
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).
Subcellular Localization :
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF).
组织特异性 :
Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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