Anti-human CD10 Monoclonal Antibody PE Conjugated, Flow Validated | 武汉博士德生物工程有限公司 FC04065-PE 产品信息

产品简要

公司名称 :

武汉博士德生物工程有限公司

产品类型 :

抗体

产品名称 :

Anti-human CD10 Monoclonal Antibody PE Conjugated, Flow Validated

FC04065-PE

规格 :

25试验, 100试验, 200试验

价格 :

89美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

克隆名称 :

FR4D11

反应物种 :

人类

应用 :

流式细胞仪

更多信息或购买 :

武汉博士德生物工程有限公司产品网页

图像

图像 1 :

Anti-human CD10 PE Conjugated, Flow Validated. Reh cells were stained with PE mouse anti-human CD10 (clone FR4D11) (red histogram). Reh cells stained with PE conjugated mouse IgG1 isotype control (Blue histogram).

产品信息

SKU号 :

FC04065-PE

状态 :

Enabled

名称 :

Anti-human CD10 Monoclonal Antibody PE Conjugated, Flow Validated

目录名称 :

一抗, 单克隆抗体, 流式细胞仪抗体

基因名称 :

MME

价格 :

89美元

price various sizes :

25试验/$89 100试验/$199 200试验/$319

克隆性 :

单克隆

克隆编号 :

FR4D11

浓度 :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

共轭标签 :

contents :

PBS, pH7.2, 0.09% NaN3和0.2%(w/v)BSA

描述 :

Monoclonal clone# G2 antibody for CD10/MME detection. Host: Mouse.Size: 25 Tests, 100 Tests, 200 Tests. Tested applications: Flow Cytometry. Reactive species: Human. CD10/MME information: Molecular Weight: 85514 MW; Subcellular Localization: Cell membrane; Single-pass type II membrane protein.

short description :

Mouse Monoclonal Anti-human CD10 PE Conjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells.

description1 :

Introduction . CD10 also known as common acute lymphoblastic leukemia antigen (CALLA), is a 100 kD protein having neutral metalloendopeptidase activity and inactivates a variety of biologically active peptides. CD10 is a type II cell surface glycoprotein typically expressed on acute lymphoblastic leukemias (ALL). In normal healthy volunteers precursors of B and T cells and granulocytes also express CD10. CD10 plays important role in the development process of B cell in germinal centers. . This antibody is routinely tested by flow cytometric analysis. Flow cytometry and other applications were tested during antibody development by CapricoBio or are reported in the literature. Application Information . Each lot of this antibody has been quality control tested by flow cytometric analysis using Reh cell line. For flow cytometric analysis 5ïl of this antibody is enough to stain 1x106 PBMCs or 100ul whole blood sample. It is strongly suggested that the antibody reactivity be empirically titrated for optimal performance in the application of interest.

规格 :

25试验, 100试验, 200试验

UniProt数据库编号 :

P08473

宿主 :

小鼠

免疫原 :

Raji cells

形式 :

Liquid

纯化 :

蛋白质A纯化

储存 :

4 C and protect from prolonged exposure to light. Do not freeze.

抗体亚型 :

IgG1, k

敏感性 :

5ul per sample

应用细节 :

Flow Cytometry, 5ul is enough to stain 1 million PBMCs or 100ul whole blood sample.

应用 :

流式细胞仪

反应物种 :

人类

图像标记 :

背景 :

CD10, also known as membrane metallo-endopeptidase, neutral endopeptidase(NEP), Neprilysin, or common acute lymphoblastic leukemia antigen(CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. CD10 has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.

研究种类 :

Angiogenesis, Atherosclerosis, Cancer, Cardiovascular, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Tumor Biomarkers

同义词 :

Neprilysin;3.4.24.11 ;Atriopeptidase;Common acute lymphocytic leukemia antigen;CALLA;Enkephalinase;Neutral endopeptidase 24.11;NEP;Neutral endopeptidase;Skin fibroblast elastase;SFE;CD10;MME;EPN;

基因全称 :

脑啡肽酶

分子量 :

85514分子量

protein function :

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

subcellular localization :

Cell membrane; Single-pass type II membrane protein.

蛋白名 :

脑啡肽酶

更新 :

2/6/19 22:57

更多信息或购买 :

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