产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗肿瘤坏死因子甲(肿瘤坏死因子α)单克隆抗体
目录 :
M00002
规格 :
100 ug/vial
价格 :
440美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
TNF706 + P/T2
反应物种 :
人类, 小鼠, 大鼠, 犬
应用 :
免疫组化
更多信息或购买 :
武汉博士德生物工程有限公司 产品网页
图像
图像 1 :
武汉博士德生物工程有限公司 M00002 图像 1
Formalin-fixed, paraffin-embedded human Erdheim Chester disease (also known as polyostotic sclerosing histiocytosis) stained withTNF alpha Monoclonal Antibody (TNF706 + P/T2).
产品信息
SKU号 :
M00002
产品名称 :
抗肿瘤坏死因子甲(肿瘤坏死因子α)单克隆抗体
价格 :
440美元
规格 :
100 ug/vial
克隆性 :
单克隆
克隆编号 :
TNF706 + P/T2
宿主 :
小鼠
反应物种 :
狗, 人类, 小鼠, 兔, 大鼠
应用(s) :
免疫组化
应用细节 :
Immunohistology (Formalin-paraffin) (2-4ug/ml for 30 min at RT).Immunofluorescence (1-2ug/ml)
描述 :
Boster Bio Anti-TNF-alpha (Tumor Necrosis Factor alpha) Monoclonal Antibody catalog # M00002. Tested in IHC applications. This antibody reacts with Canine, Human, Mouse, Rabbit, Rat.
浓度 :
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
基因名称 :
肿瘤坏死因子
UniProt数据库编号 :
P01375
免疫原 :
Recombinant N-terminal fragment of human TNF-? (TNF706); Peptide corresponding to aa115-130 of human TNF-? (P/T2)
形式 :
液体
Contents :
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
纯化 :
Bioreactor Concentrate
抗体亚型 :
IgM, kappa
储存 :
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
基因全称 :
肿瘤坏死因子
同义词 :
Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Tumor necrosis factor, membrane form; N-terminal fragment; NTF; Intracellular domain 1; ICD1; Intracellular domain 2; ICD2; C-domain 1; C-domain 2; Tumor necrosis factor, soluble form; TNF; TNFA, TNFSF2;
分子量 :
25644分子量
Protein Function :
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
Subcellular Localization :
Cell membrane ; Single-pass type II membrane protein.
研究种类 :
Atherosclerosis, Cancer, Cardiovascular, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Metabolism, Signal Transduction, Tnf Superfamily, Vascular Inflammation
更多信息或购买 :
武汉博士德生物工程有限公司 产品网页
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
Premium Provider of Antibodies and ELISA Kits