产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗磷酸酶张力蛋白同源基因兔单克隆抗体, Clone#RM265
目录 :
M00006-3
规格 :
100微升
价格 :
289美元
克隆性 :
单克隆
宿主 :
共轭标签 :
nonconjugated
克隆名称 :
RM265
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化
图像
图像 1 :
武汉博士德生物工程有限公司 M00006-3 图像 1
Figure 2. IHC result. Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue sections using Anti-PTEN Rabbit Monoclonal Antibody (Clone RM265) at a 1:1000 dilution.
产品信息
SKU号 :
M00006-3
状态 :
Enabled
名称 :
抗磷酸酶张力蛋白同源基因兔单克隆抗体, Clone#RM265
目录名称 :
一抗, 单克隆抗体, 兔单克隆抗体, 免疫组化免疫细胞化学IF抗体
基因名称 :
磷酸酶张力蛋白同源基因
价格 :
289美元
克隆性 :
单克隆
克隆编号 :
RM265
浓度 :
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
共轭标签 :
No
contents :
50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
描述 :
Anti-PTEN Rabbit Monoclonal Antibody, Clone#RM265 tested in WB, IHC, reactive to Human (Mouse)
short description :
Anti-PTEN Rabbit Monoclonal Antibody, Clone#RM265 tested in WB, IHC, reactive to Human (Mouse)
规格 :
100微升
UniProt数据库编号 :
P60484
宿主 :
免疫原 :
A peptide corresponding to the C-terminus of human PTEN
储存 :
-20 C
应用细节 :
免疫组化(免疫组化):1:1000-1:2000稀释;免疫印迹(免疫印迹):1:1000-1:2000稀释
应用 :
免疫组化, 免疫印迹
反应物种 :
人类, 小鼠
图像标记 :
Figure 1. Western Blotting result. Western Blot of HeLa and 293 cells lysates using Anti-PTEN Rabbit Monoclonal Antibody (Clone RM265) at a 1:1000 dilution. Figure 2. IHC result. Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue sections using Anti-PTEN Rabbit Monoclonal Antibody (Clone RM265) at a 1:1000 dilution.
研究种类 :
Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Diabetes, Epigenetics And Nuclear Signaling, Kinases/Phosphatases, Lipid Signaling, Metabolism, Obesity, Oncoproteins/Suppressors, Signal Transduction, Signaling Pathway, Transcription, Tumor Suppressors
同义词 :
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;3.1.3.16 ;3.1.3.48 ;3.1.3.67 ;Mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;PTEN;MMAC1, TEP1;
基因全称 :
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
分子量 :
47166分子量
protein function :
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.
subcellular localization :
Cytoplasm . Nucleus . Nucleus, PML body . Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982).
组织特异性 :
Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
更新 :
2/8/19 6:55
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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