其他

Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody

M00010

100 ug/vial

299美元

Enabled

Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody

一抗, 单克隆抗体, 免疫组化免疫细胞化学IF抗体

v-erb-b2成红细胞白血病病毒致瘤基因2

299美元

20ug sample size / $99 100ug / $299 100ug+Free HRP Secondary BA1050 / $299 100ug+Free Biotin Secondary BA1001 / $299

单克隆

ERB2/776

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

No

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Mouse Monoclonal Antibody [Clone ERB2/776] antibody for Her2/ERBB2 detection. Host: Mouse.Size: 100ug/vial. Tested applications: IF. Reactive species: Human. Her2/ERBB2 information: Molecular Weight: 137910 MW; Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1; Tissue Specificity: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Anti-HER-2 / c-erbB-2 / neu / CD340 Antibody

100 ug/vial

20ug for $99, contact us for details

P04626

小鼠

Recombinant intracellular domain of human HER-2 protein

Liquid

Immunohistology (Formalin-fixed ) (0.5-1ug/ml for 30 min at Room Temp). Immunofluorescence (0.5-1ug/ml)

免疫组化

人类

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained withHER-2 Monoclonal Antibody (ERB2/776).

Cancer, Cell Type Markers, Growth Factors, Growth Factors/Hormones, Oncoproteins, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tags & Cell Markers, Tumor Associated, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens, Tyrosine Kinases

Receptor tyrosine-protein kinase erbB-2;2.7.10.1;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD340;ERBB2;HER2, MLN19, NEU, NGL;

Receptor tyrosine-protein kinase erbB-2

137910分子量

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

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