抗雌激素受体α抗体(单克隆, C-542) | 武汉博士德生物工程有限公司 M00057 产品信息

产品简要

公司名称 :

武汉博士德生物工程有限公司

产品类型 :

其他

产品名称 :

抗雌激素受体α抗体(单克隆, C-542)

M00057

规格 :

200 ug/vial

价格 :

381美元

更多信息或购买 :

武汉博士德生物工程有限公司产品网页

图像

图像 1 :

Human Estrogen Alpha Receptor domains.

图像 2 :

Western blot analysis of Estrogen Receptor Alpha expression in MW marker (lane 1) and Estrogen Receptor 1 (lane 2). Estrogen Receptor Alpha at 92KD was detected using mouse anti- Estrogen Receptor Alpha Antigen Affinity purified monoclonal antibody (Catalog # M00057) at 1:500. The blot was developed using colorimetric method.

产品信息

SKU号 :

M00057

状态 :

Enabled

名称 :

抗雌激素受体α抗体(单克隆, C-542)

目录名称 :

一抗, 单克隆抗体

基因名称 :

ESR1

价格 :

381美元

price various sizes :

200ug / $381 200ug+Free HRP Secondary BA1050 / $381 200ug+Free Biotin Secondary BA1001 / $381

克隆性 :

单克隆

克隆编号 :

C-542

浓度 :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

共轭标签 :

contents :

Each vial contains 50% glycerol and 0.09% sodium azide.

描述 :

Monoclonal, C-542 antibody for ESTROGEN RECEPTOR ALPHA/ESR1 detection. Host: Mouse.Size: 200ug/vial. Tested applications: IP. Reactive species: Human. ESTROGEN RECEPTOR ALPHA/ESR1 information: Molecular Weight: 66216 MW; Subcellular Localization: Isoform 1: Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . A minor fraction is associated with the inner membrane; Tissue Specificity: Widely expressed. Isoform 3 is not expressed in the pituitary gland.

short description :

Mouse Anti-Estrogen Receptor Alpha Antibody (Monoclonal, C-542) for ESR1 detectiontested for IP, WB in Human, Mouse, Rat.

规格 :

200 ug/vial

UniProt数据库编号 :

P03372

宿主 :

小鼠

免疫原 :

Synthetic peptide corresponding to the sequence near the C-terminus of human Estrogen Receptor alpha .

形式 :

Liquid

纯化 :

蛋白质G亲和纯化

应用细节 :

WB, 1:500, colorimetric, Human, Mouse, Rat

应用 :

免疫沉淀, 免疫印迹

反应物种 :

人类, 小鼠, 大鼠

图像标记 :

Human Estrogen Alpha Receptor domains. Western blot analysis of Estrogen Receptor Alpha expression in MW marker (lane 1) and Estrogen Receptor 1 (lane 2). Estrogen Receptor Alpha at 92KD was detected using mouse anti- Estrogen Receptor Alpha Antigen Affinity purified monoclonal antibody (Catalog # M00057) at 1:500. The blot was developed using colorimetric method.

背景 :

The estrogen receptor alpha (ERalpha, UniProt/Swiss-Prot entry P03372) belongs to the family of nuclear hormone receptors, which are ligand-activated transcription factors. They are important for the regulation of gene expression, cellular proliferation and differentiation, sexual development and reproductive function. Estrogen receptors are also involved in pathological processes such as breast cancer, and osteoporosis. ERalpha can regulate transcription by direct binding to estrogen response elements (EREs) in the DNA or by interaction with other transcription factors. It may also form a heterodimer with ERbeta.

研究种类 :

Cancer, Chip'Ing Antibodies, Endocrine System, Epigenetics And Nuclear Signaling, Neuroscience, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway

同义词 :

Estrogen receptor;ER;ER-alpha;Estradiol receptor;Nuclear receptor subfamily 3 group A member 1;ESR1;ESR, NR3A1;

基因全称 :

雌激素受体

分子量 :

66216分子量

protein function :

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.

subcellular localization :

Isoform 1: Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . A minor fraction is associated with the inner membrane.

组织特异性 :

Widely expressed. Isoform 3 is not expressed in the pituitary gland.

蛋白名 :

雌激素受体(ESR1)

更新 :

2/6/19 22:57

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