抗体

抗IRF7兔单克隆抗体

M00115

100微升

315美元

单克隆

domestic rabbit

未共轭

FAH-9

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪

抗IRF7兔单克隆抗体

315美元

100微升

单克隆

FAH-9

兔

人类, 小鼠, 大鼠

流式细胞仪, 免疫沉淀, IF, 免疫组化, 免疫细胞化学, 免疫印迹

免疫印迹1:500-1:2000。 免疫组化1:50-1:200。 免疫细胞化学/IF 1:50-1:200。 免疫沉淀1:50。 流式细胞仪1:50

Boster Bio Anti-IRF7 Rabbit Monoclonal Antibody catalog # M00115. Tested in Flow Cytometry, IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

IRF7

Q92985

A synthesized peptide derived from human IRF7

液体

兔IgG在磷酸盐缓冲液, pH值7.4, 150mM氯化钠, 0.02% 叠氮化钠和50% 甘油, 0.4 0.5毫克/毫升BSA

亲和色谱

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

干扰素调节因子7

干扰素调节因子7;IRF-7;IRF7;

54278分子量

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.

Expressed predominantly in spleen, thymus and peripheral blood leukocytes.

Antiviral Signaling, Cytokines, Domain Families, Epigenetics and Nuclear Signaling, Hlh / Leucine Zipper, Host Virus Interaction, Immune System Diseases, Immunology, Innate Immunity, Interferons, Interspecies Interaction, Microbiology, Pol Ii Transcription, Polymerase Associated Factors, Tlr Signaling, Transcription