其他

Anti-PCNA (Proliferating Cell Nuclear Antigen) (G1- & S-phase Marker) Monoclonal Antibody

M00125

100 ug/vial

299美元

Enabled

Anti-PCNA (Proliferating Cell Nuclear Antigen) (G1- & S-phase Marker) Monoclonal Antibody

一抗, 单克隆抗体, 免疫组化免疫细胞化学IF抗体

增殖细胞核抗原

299美元

20ug sample size / $99 100ug / $299 100ug+Free HRP Secondary BA1050 / $299 100ug+Free Biotin Secondary BA1001 / $299

单克隆

SPM350

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

No

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Mouse Monoclonal Antibody [Clone SPM350] antibody for PCNA detection. Host: Mouse.Size: 100ug/vial. Tested applications: IF. Reactive species: Chicken. PCNA information: Molecular Weight: 28769 MW; Subcellular Localization: Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.

Anti-PCNA (Proliferating Cell Nuclear Antigen) (G1- & S-phase Marker) Antibody

100 ug/vial

20ug for $99, contact us for details

P12004

小鼠

大鼠增殖细胞核抗原/蛋白质A融合蛋白

Liquid

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. ,Antibody is stable for 24 months.

Immunohistology (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT). Immunofluorescence (0.5-1ug/ml)

免疫组化

Chicken, Drosophila, Human, Monkey, Mouse, Pig, Rat, Yeast, Zebrafish

Formalin-fixed, paraffin-embedded human Tonsil stained withPCNA Monoclonal Antibody (SPM350)

sc 65598 sc 56 sc 9857 sc 71858 sc 27912 sc 33756 sc 12849 sc 34005 sc 53408 sc 53407 sc 7907 sc 25280 sc 9857 R

Cancer, Cell Biology, Cell Cycle, Cell Division, Cell Type Markers, Chromatin Binding Proteins, Dna / Rna, Dna / Rna Binding, Dna Synthesis, Epigenetics And Nuclear Signaling, Tags & Cell Markers, Tumor Antigens, Tumor Biomarkers

增殖细胞核抗原;增殖细胞核抗原;细胞周期蛋白;增殖细胞核抗原;

增殖细胞核抗原

28769分子量

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.

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