产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗PR PGR单克隆抗体
目录 :
M00541-2
规格 :
100微升
价格 :
380美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Z15
反应物种 :
人类
应用 :
免疫组化, 免疫细胞化学
产品信息
SKU号 :
M00541-2
产品名称 :
抗PR PGR单克隆抗体
价格 :
380美元
规格 :
100微升
克隆性 :
单克隆
克隆编号 :
Z15
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用(s) :
IF, 免疫组化
应用细节 :
免疫组化1:200.IF:1:100-200
描述 :
Boster Bio Anti-PR PGR Monoclonal Antibody catalog # M00541-2. Tested in IF, IHC applications. This antibody reacts with Human, Mouse, Rat.
浓度 :
1毫克/毫升
基因名称 :
PGR
UniProt数据库编号 :
P06401
免疫原 :
合成肽
形式 :
液体
Contents :
液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠
纯化 :
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
抗体亚型 :
IgG
储存 :
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
基因全称 :
巨噬细胞集落刺激因子1受体
同义词 :
Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; 2.7.10.1; Proto-oncogene c-Fms; CD115; CSF1R; FMS;
蛋白名 :
巨噬细胞集落刺激因子1受体
分子量 :
107984分子量
Protein Function :
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
Subcellular Localization :
Cell membrane; Single-pass type I membrane protein.
组织特异性 :
Expressed in bone marrow and in differentiated blood mononuclear cells.
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
Premium Provider of Antibodies and ELISA Kits