抗体

抗Wnt5a兔单克隆抗体

M00549

100微升

315美元

单克隆

domestic rabbit

未共轭

ABEE-23

免疫印迹, 免疫细胞化学, 流式细胞仪

抗Wnt5a兔单克隆抗体

315美元

100微升

单克隆

ABEE-23

兔

人类

流式细胞仪, IF, 免疫细胞化学, 免疫印迹

免疫印迹1:500-1:1000。 免疫细胞化学/IF 1:50-1:200。 流式细胞仪1:20

Boster Bio Anti-Wnt5a Rabbit Monoclonal Antibody catalog # M00549. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human.

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

WNT5A

P41221

A synthesized peptide derived from human Wnt5a

液体

兔IgG在磷酸盐缓冲液, pH值7.4, 150mM氯化钠, 0.02% 叠氮化钠和50% 甘油, 0.4 0.5毫克/毫升BSA

亲和色谱

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

蛋白Wnt 5a

蛋白Wnt 5a;WNT5A;

42339分子量

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Secreted, extracellular space, extracellular matrix.

Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).

Cancer, Neural Signal Transduction, Neurology Process, Neuroscience, Oncoproteins/Suppressors, Secreted, Signaling Pathways, Stem Cells, Tumor Suppressors