抗体

抗纤连蛋白FN1单克隆抗体

M00564-2

100微升

380美元

单克隆

小鼠

未共轭

M9

抗纤连蛋白FN1单克隆抗体

380美元

100微升

单克隆

M9

小鼠

人类, 小鼠, 大鼠

免疫印迹

免疫印迹1:1000-2000

Boster Bio Anti-Fibronectin FN1 Monoclonal Antibody catalog # M00564-2. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

1毫克/毫升

FN1

P02751

合成肽

液体

液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

IgG

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

肿瘤蛋白63

Tumor protein 63; p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51; TP63; KET, P63, P73H, P73L, TP73L;

肿瘤蛋白63

76785分子量

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Nucleus

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.