产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗CD61/整合素乙3/血小板糖蛋白Ⅲa(血小板标记)ITGB3单克隆抗体
目录 :
M00587
规格 :
100 ug/vial
价格 :
440美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
ITGB3/1713
反应物种 :
人类
应用 :
免疫组化
图像
图像 1 :
武汉博士德生物工程有限公司 M00587 图像 1
Formalin-fixed, paraffin-embedded human Spleen stained withCD61 Monoclonal Antibody (ITGB3/1713).
产品信息
SKU号 :
M00587
产品名称 :
抗CD61/整合素乙3/血小板糖蛋白Ⅲa(血小板标记)ITGB3单克隆抗体
价格 :
440美元
规格 :
100 ug/vial
克隆性 :
单克隆
克隆编号 :
ITGB3/1713
宿主 :
小鼠
反应物种 :
人类
应用(s) :
免疫组化
应用细节 :
Immunohistology (Frozen & Formalin-fixed) (1-2ug/ml for 30 minutes at RT).Immunofluorescence (0.5-1ug/ml)
描述 :
Boster Bio Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody catalog # M00587. Tested in IHC applications. This antibody reacts with Human.
浓度 :
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
基因名称 :
ITGB3
UniProt数据库编号 :
P05106
免疫原 :
重组人类ITGB3蛋白
形式 :
液体
Contents :
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
纯化 :
蛋白质A/G
抗体亚型 :
IgG1, kappa
储存 :
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
基因全称 :
整合素乙3
同义词 :
整合素乙3;血小板膜糖蛋白IIIa;糖蛋白Ⅲa;CD61;ITGB3;GP3A;
分子量 :
87058分子量
Protein Function :
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Subcellular Localization :
Cell membrane ; Single- pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion.
组织特异性 :
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
研究种类 :
Cell Adhesion, Cell Cycle, Chromosome Structure, Co-Activators/Co-Repressors, Cytoskeleton / Ecm, Epigenetics and Nuclear Signaling, Integrins, Nfkb Pathway, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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