产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-Optineurin/OPTN Picoband Antibody (monoclonal, 3D8)
目录 :
M00952
规格 :
100 ug/vial
价格 :
240美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
3D8
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 流式细胞仪
图像
图像 1 :
武汉博士德生物工程有限公司 M00952 图像 1
Boster Kit Box
产品信息
SKU号 :
M00952
状态 :
Enabled
名称 :
Anti-Optineurin/OPTN Picoband Antibody (monoclonal, 3D8)
目录名称 :
一抗, 单克隆抗体
基因名称 :
OPTN
价格 :
240美元
克隆性 :
单克隆
克隆编号 :
3D8
浓度 :
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
共轭标签 :
No
contents :
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
描述 :
Mouse IgG monoclonal antibody for Optineurin/OPTN detection. Tested with WB, FCM in Human;Mouse;Rat.
short description :
Mouse IgG monoclonal antibody for Optineurin/OPTN detection. Tested with WB, FCM in Human;Mouse;Rat.
规格 :
100 ug/vial
UniProt数据库编号 :
Q96CV9
宿主 :
小鼠
免疫原 :
E.coli-derived human Optineurin recombinant protein (Position: R241-I577). Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse and rat Optineurin.
形式 :
冻干
储存 :
At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time. Avoid repeated freezing and thawing.
交叉活性 :
No cross reactivity with other proteins.
抗体亚型 :
IgG2b
重组 :
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
应用细节 :
免疫印迹, 0.1 0.5微克/毫升。 流式细胞仪, 1-3微克/1x10 6细胞
应用 :
流式细胞仪, 免疫印迹
反应物种 :
人类, 小鼠, 大鼠
图像标记 :
Boster Kit Box
背景 :
OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
研究种类 :
Adapters, Cytokines, Cytoplasmic, Immunology, Innate Immunity, Neuroscience, Sensory System, Signal Transduction, Tnf Superfamily, Visual System
同义词 :
Optineurin; E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7;HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntP; OPTN; FIP2; GLC1E; HIP7; HYPL; NRP
基因全称 :
optineurin
protein function :
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
subcellular localization :
Golgi apparatus. Trans-Golgi network. Recycling endosome. Perinuclear region. Autophagosome. Cytoplasmic vesicle.
组织特异性 :
Present in aqueous humor of the eye. Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
recommended detection systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
更新 :
2/11/19 19:36
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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