抗体

抗Ku80 XRCC5兔单克隆抗体

M01275

100微升

315美元

单克隆

domestic rabbit

未共轭

FAE-24

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

抗Ku80 XRCC5兔单克隆抗体

315美元

100微升

单克隆

FAE-24

兔

人类

免疫沉淀, IF, 免疫组化, 免疫细胞化学, 免疫印迹

免疫印迹1:5000-1:10000。 免疫组化1:50-1:200。 免疫细胞化学/IF 1:100-1:500。 免疫沉淀1:50

Boster Bio Anti-Ku80 XRCC5 Rabbit Monoclonal Antibody catalog # M01275. Tested in IP, IF, IHC, ICC, WB applications. This antibody reacts with Human.

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

XRCC5

P13010

A synthesized peptide derived from human Ku80

液体

兔IgG在磷酸盐缓冲液, pH值7.4, 150mM氯化钠, 0.02% 叠氮化钠和50% 甘油, 0.4 0.5毫克/毫升BSA

亲和色谱

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

X-ray repair cross-complementing protein 5

X-ray repair cross-complementing protein 5; 3.6.4.-; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Lupus Ku autoantigen protein p86; Nuclear factor IV; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); XRCC5; G22P2;

82705分子量

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V (D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'- deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

Nucleus. Nucleus, nucleolus. Chromosome.

DNA / RNA, Epigenetics and Nuclear Signaling