抗水闸蛋白1 CLDN1兔单克隆抗体 | 武汉博士德生物工程有限公司 M01585 产品信息

产品简要

公司名称 :

武汉博士德生物工程有限公司

产品类型 :

抗体

产品名称 :

抗水闸蛋白1 CLDN1兔单克隆抗体

M01585

规格 :

100微升

价格 :

315美元

克隆性 :

单克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

克隆名称 :

ABEH-3

反应物种 :

人类

应用 :

免疫印迹

更多信息或购买 :

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产品信息

SKU号 :

M01585

产品名称 :

抗水闸蛋白1 CLDN1兔单克隆抗体

价格 :

315美元

规格 :

100微升

克隆性 :

单克隆

克隆编号 :

ABEH-3

宿主 :

兔

反应物种 :

人类, 小鼠, 大鼠

应用(s) :

免疫印迹

应用细节 :

免疫印迹1:500-1:2000

描述 :

Boster Bio Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody catalog # M01585. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

浓度 :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

基因名称 :

CLDN1

UniProt数据库编号 :

O95832

免疫原 :

A synthesized peptide derived from human Claudin 1

形式 :

液体

Contents :

兔IgG在磷酸盐缓冲液, pH值7.4, 150mM氯化钠, 0.02% 叠氮化钠和50% 甘油, 0.4 0.5毫克/毫升BSA

纯化 :

亲和色谱

储存 :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

基因全称 :

水闸蛋白1

同义词 :

Claudin-1; Senescence-associated epithelial membrane protein; CLDN1; CLD1, SEMP1; UNQ481/PRO944;

分子量 :

22744分子量

Protein Function :

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).

Subcellular Localization :

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

组织特异性 :

Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.

研究种类 :

Cell Adhesion, Cytoskeleton / Ecm, Signal Transduction, Tight Junctions

更多信息或购买 :

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公司信息