产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗p16INK4a/CDKN2抗体(单克隆, DCS-50)
目录 :
MA1074
规格 :
100μg/vial
价格 :
315美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
DCS-50
反应物种 :
人类, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
图像
图像 1 :
Boster Kit Box
产品信息
SKU号 :
MA1074
产品名称 :
抗p16INK4a/CDKN2抗体(单克隆, DCS-50)
价格 :
315美元
规格 :
100μg/vial
克隆性 :
单克隆
克隆编号 :
DCS-50
宿主 :
小鼠
反应物种 :
人类
应用(s) :
免疫组化, 免疫细胞化学, 免疫印迹
应用细节 :
Immunocytochemistry , 1µg/ml, HumanImmunohistochemistry (Frozen Section), 1-2µg/ml, Human Western blot, 0.5-1µg/ml, Human.
应用注释 :
Other applications have not been tested.
Optimal dilutions should be determined by end users.
描述 :
Boster Bio Anti-p16INK4a/CDKN2 Antibody (Monoclonal, DCS-50) catalog # MA1074. Tested in IHC, ICC, WB applications. This antibody reacts with Human.
浓度 :
Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.
基因名称 :
CDKN2A
UniProt数据库编号 :
Q9R0Z3
免疫原 :
重组人类p16蛋白
形式 :
冻干
Contents :
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
纯化 :
腹水
交叉活性 :
No cross reactivity with other proteins
抗体亚型 :
小鼠IgG1
储存 :
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
重组 :
Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
基因全称 :
Cyclin-dependent kinase inhibitor 2A
同义词 :
Cyclin-dependent kinase inhibitor 2A ; Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16; p16-INK4; Cdkn2a ; P16ink4a ;
蛋白名 :
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
分子量 :
17366分子量
Protein Function :
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity).
Subcellular Localization :
Cytoplasm. Nucleus.
组织特异性 :
Expressed in spleen, liver and lung. Not detected in kidney, colon, stomach or brain.
Recommended Detection Systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(F) and ICC.
Sequence Similarities :
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
背景 :
p16 (INK4A), also known as cyclin-dependent kinase inhibitor 2A (CDKN2A), or multiple tumor suppressor 1 (MTS1). The p16 gene (CDKN2A) was mapped to 9p21. The p16 gene encodes a negative regulator of the cell cycle. CDKN2 plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. Germ-line mutations in the CDKN2A tumor-suppressor gene have been linked to the development of melanoma in some families with inherited melanoma.
研究种类 :
Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, P53 Pathway, Transcription, Tumor Suppressors
更多信息或购买 :
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn925.485.4527
公司总部: 美国
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