产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗磷酸化p53(Ser392)TP53抗体
目录 :
P00001
规格 :
100微升
价格 :
435美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
多克隆
反应物种 :
人类
应用 :
免疫印迹
产品信息
SKU号 :
P00001
状态 :
1
名称 :
抗磷酸化p53(Ser392)TP53抗体
url key :
抗p53-ser392
产品种类 :
一抗
基因名称 :
TP53
价格 :
435
规格1 :
100微升
price for size 1 :
435美元
规格2 :
100uL+Free Secondary Ab BA1054
price for size 2 :
435
规格3 :
100uL+Free Secondary Ab BA1003
price for size 3 :
435
克隆性 :
多克隆
浓度 :
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
contents :
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.
描述 :
Boster Bio Anti-Phospho-p53 (Ser392) TP53 Antibody catalog # P00001. Tested in WB applications. This antibody reacts with Rat.
short description :
Boster Bio Anti-Phospho-p53 (Ser392) TP53 Antibody catalog # P00001. Tested in WB applications. This antibody reacts with Rat.
规格 :
100ul
UniProt数据库编号 :
P04637
宿主 :
免疫原 :
The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser392 of human p53.
形式 :
液体
储存 :
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
应用细节 :
免疫印迹, 1:1, 000
应用 :
免疫印迹
反应物种 :
大鼠
前体活性 :
人类
images :
/P/0/P00001-Western_blot-testing-image-1.gif
图像标记 :
Western blot of rat brain nuclear fraction lysate showing specific immunolabeling of the ~53 kDa p53 phosphorylated at Ser 392 in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is completely eliminated by blot treatment with lambda phosphatase (gamma-Ptase 1200 units for 30 minutes).
custom options :
name=Size,required=1,price=0.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=100uL name=Size,required=1,price=0.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=100uL+Free Secondary Ab BA1054 name=Size,required=1,price=0.0000,type=radio,sku=,max_characters=0,file_extension=,image_size_x=0,image_size_y=0,price_type=fixed,option_title=100uL+Free Secondary Ab BA1003
created at :
12/15/16 6:48
updated at :
6/21/21 7:03
meta title :
Anti-Phospho-p53 (Ser392) Antibody (P00001) Bosterbio
meta keyword :
抗磷酸化p53(Ser392)TP53抗体
meta description :
Boster Bio Anti-Phospho-p53 (Ser392) TP53 Antibody catalog # P00001. Tested in WB applications. This antibody reacts with Rat. Supplied as 100ul in Liquid form antibody.
rating value :
99.1
研究种类 :
Apoptosis,Cell Biology,Intracellular,P53 Pathway
同义词 :
Cellular tumor antigen p53;Antigen NY-CO-13;Phosphoprotein p53;Tumor suppressor p53;TP53;P53;
基因全称 :
Cellular tumor antigen p53
分子量 :
43653分子量
protein function :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1- mediated transcriptional activation of PER2 (PubMed:24051492).
subcellular localization :
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress.
组织特异性 :
Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
蛋白名 :
Cellular tumor antigen p53
custom attribute 6 :
Western blot of rat brain nuclear fraction lysate showing specific immunolabeling of the ~53 kDa p53 phosphorylated at Ser 392 in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is completely eliminated by blot treatment with lambda phosphatase (gamma-Ptase 1200 units for 30 minutes).
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn
925.485.4527
公司总部: 美国
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