抗磷酸化STAT3 Y705抗体 | 武汉博士德生物工程有限公司 P00007 产品信息

产品简要

公司名称 :

武汉博士德生物工程有限公司

产品类型 :

抗体

产品名称 :

抗磷酸化STAT3 Y705抗体

P00007

规格 :

100微克

价格 :

298美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

nonconjugated

反应物种 :

人类

应用 :

免疫印迹, 免疫组化

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产品信息

SKU号 :

P00007

名称 :

抗磷酸化STAT3 Y705抗体

价格 :

298美元

形式 :

Liquid

宿主 :

兔

克隆性 :

多克隆

描述 :

Anti-STAT3 phospho Y705 Antibody validated for WB in Human.

规格 :

100微克

反应物种 :

人类

应用 :

免疫组化;免疫印迹

背景 :

The transcription factor, signal transducer and activator of transcription-3(STAT-3) is the most pleiotropic member of the signal transducer and activator of transcription(STAT) family of transcription factors and mediates pivotal responses for the cytokine family. The mouse STAT3 gene contains 24 exons and spans 30 kb. The translation initiation codon is in exon 2, and the stop codon is in exon 24. STAT3 is mapped to 17q21, it contributes to various physiological processes. Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus.

浓度 :

1.0 mg/mL by UV absorbance at 280 nm

基因全称 :

Signal transducer and activator of transcription 3

基因名称 :

STAT3

protein function :

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

研究种类 :

signal transduction signaling pathway nuclear signaling stats epigenetics and nuclear signaling transcription other factors stem cells embryonic stem cells intracellular nuclear signaling pathways cancer stat family cardiovascular heart cardiogenesis transcription factors/regulators hypertrophy transcription factors developmental biology embryogenesis surface molecules

subcellular localization :

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.

同义词 :

Signal transducer and activator of transcription 3;Acute-phase response factor;STAT3;APRF;

组织特异性 :

心, 大脑, 胎盘, 肺, 肝, 骨骼肌, 肾脏和胰腺

UniProt数据库编号 :

P40763

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公司信息