抗体

抗磷酸化HER2(Tyr1248)抗体

P00010

100微升

269美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗磷酸化HER2(Tyr1248)抗体

269美元

Peptide sequence around phosphorylation site of tyrosine1248 (P-E-Y(p)-L-G) derived from Human HER2.

Liquid

兔

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免疫原亲和纯化

多克隆

Rabbit Polyclonal Antibody for Phospho-HER2 (Tyr1248) (ERBB2) detection. Tested with WB, IHC, IF in Human, Mouse, Rat.

100微升

人类;小鼠;大鼠

IF;免疫组化;免疫印迹

Receptor tyrosine-protein kinase erbB-2

v-erb-b2成红细胞白血病病毒致瘤基因2

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

tags & cell markers cell type markers tumor associated signal transduction protein phosphorylation tyrosine kinases receptor tyrosine kinases growth factors/hormones egf cancer growth factors tumor immunology tumor-associated antigens tumor biomarkers oncoproteins

Store at -20 for one year, at 4 for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20℃ upon receiving. Avoid repeated freezing and thawing.

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.

Receptor tyrosine-protein kinase erbB-2;2.7.10.1;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD340;ERBB2;HER2, MLN19, NEU, NGL;

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

P04626