抗体

抗磷酸化表皮生长因子受体(Y1173)兔单克隆抗体, Clone#RM269

P00023-5

100微升

399美元

单克隆

domestic rabbit

未共轭

RM269

免疫印迹, 免疫组化

抗磷酸化表皮生长因子受体(Y1173)兔单克隆抗体, Clone#RM269

399美元

100微升

单克隆

RM269

兔

人类

免疫印迹, 免疫组化

免疫组化(免疫组化):1:500-1:1000稀释;免疫印迹(免疫印迹):1:1000-1:5000稀释

Boster Bio Anti-Phospho-EGFR (Y1173) Rabbit Monoclonal Antibody, Clone#RM269 catalog # P00023-5. Tested in IHC, WB applications. This antibody reacts with Human.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

表皮生长因子受体

P00533

A phospho-peptide corresponding to human Phospho- EGFR (Tyr1173)

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

表皮生长因子受体

Epidermal growth factor receptor; 2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR; ERBB, ERBB1, HER1;

134277分子量

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF).

Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.

Cancer, Growth Factors/Hormones, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tumor Biomarkers, Tyrosine Kinases